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Medical News Today: Common foods alter gut bacteria by influencing viruses

A group of researchers has brought the idea of food as a medicine one step closer. They have identified certain common foodstuffs that alter our microbiome.

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Illustration of phage viruses attacking a bacterium.

In science today, food and gut bacteria are two topics that are guaranteed to fuel interest and debate. Both, of course, are interrelated, and a new study focuses on some subtleties of this relationship.

The lack of a healthy population of gut bacteria compromises our health; the same is true when we do not eat a healthful diet. However, scientists do not entirely understand the exact impact of specific foods on gut bacteria.

This knowledge gap is due, in part, to the unbelievable complexity of the microbiome. One factor that muddies the water is bacteriophages, or phages for short.

The phage

Phages are viruses that only attack bacteria. Within the gut, these viruses outnumber the dizzyingly numerous gut bacteria.

Each phage only attacks a specific type of bacterium, meaning that it can influence levels of gut bacteria. Phages need bacteria to live, so if bacteria are absent, the phages cannot survive.

This means that any foods that influence phages can influence gut bacteria and vice versa. For example, if the population of one type of phage increases, the bacteria that they consume will dwindle, potentially making room for another species of bacteria to multiply.

In this way, viruses can affect the overall microbiome — by pruning one species, they provide space for other species to fill.

Switching from prophage

Most phages in the gut are present in a dormant form — their DNA is integrated into the bacteria's genome. In this form, they are called prophages.

Scientists have identified certain compounds that trigger prophages to return to their active form. When this happens, hundreds of new phages burst out of the bacterial cell, killing the host and attacking other bacteria; these compounds include soy sauce, nicotine, and some antibiotics, such as ciprofloxacin. To date, the list of phage-promoting compounds is relatively short.

It is essential to uncover which chemicals fuel phage activity. Because phages attack and kill bacteria, if we understand how to manipulate them, they could work as powerful, natural antibiotics.

A recent study set out to expand the list of compounds that induce phage activity. The scientists from San Diego State University, CA, published their findings in the journal Gut Microbes. They hope that their results will introduce the "possibility of using diet to intentionally landscape the human gut microbiome via prophage induction."

"We could actually tackle certain conditions by adjusting the foods we consume that will affect microbial diversity, which in turn will influence health and diseases."

Research associate Lance Boling

To investigate, the researchers chose a wide range of compounds that might influence phage activity. They selected a range of bacteria from two phyla that are common in the gut: Bacteroidetes and Firmicutes. They included both beneficial and pathogenic strains of bacteria.

From 117 food compounds, they narrowed down their search to just 28. The researchers observed the growth of bacteria in the presence of each specific compound; they also observed its growth without the compound as a control. Next, they used flow cytometry, a process that is sensitive enough to detect unimaginably small virus particles.

Which foods influence phages?

Of the 28 candidates, 11 compounds produced levels of virus particles at a rate higher than the controls, which signifies that they influenced phage activity.

Some of the most significant phage boosts occurred in the presence of clove, propolis (a compound produced by bees), uva ursi (also known as kinnikinnick or bearberry), and aspartame.

The most potent prophage inducer was stevia, which is a plant-derived sugar substitute. With some species of the bacterial strains, stevia increased the number of virus particles by more than 400%.

Conversely, some foods reduced the number of virus particles; most notably, these included rhubarb, fernet (a type of Italian liquor), coffee, and oregano.

To complicate matters, some compounds boosted phage activity associated with some bacteria, but reduced phage activity related to others; these compounds include toothpaste, grapefruit seed extract, and pomegranate.

According to the authors, one of the most potent antibacterial foods was hot tabasco sauce, which "reduced the growth of all three [gastrointestinal] species, except the opportunistic pathogen P. aeruginosa, by an average of 92%."

Tabasco contains vinegar, but when they tested vinegar alone, it only reduced bacterial growth by 71%. They believe that capsaicin — the spicy compound in chilis — may explain the additional antibacterial capabilities. However, in the experiments with tabasco, no virus particles were found, so phages are unlikely to be involved.

The future

These findings are important. Scientists now know that the microbiome can influence our physical and mental health; it can also cause inflammation and increase cancer risk. If scientists can work out how to alter the microbiome in specific ways, they can, in theory, remove or reduce these risks.

As one of the authors, Forest Rohwer, explains, "The ability to kill specific bacteria, without affecting others, makes these compounds very interesting."

The new list of compounds is by no means exhaustive, of course, as Rohwer says, "There are probably thousands of compounds that would be useful for eliminating unwanted bacteria."

The authors hope that scientists will continue along these lines. They also explain that scientists will need to try to figure out the molecular mechanisms that switch the phage from inactivity to activity.

Original Article

Medical News Today: Gastroenterologists: What to know

A gastroenterologist is a medical professional who specializes in conditions that affect the organs and structures of the digestive system.

Gastroenterologists diagnose, treat, and care for people with a range of gut-related illnesses. These include long-term conditions, such as inflammatory bowel disease (IBD) and celiac disease.

What is gastroenterology?

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A person may visit a gastroenterologist if they have a condition relating to the digestive system.

Gastroenterology is a subspecialty of internal medicine.

It relates to the study of the function and diseases of the gastrointestinal tract and the digestive system.

According to the American College of Gastroenterology, gastroenterology involves a detailed understanding of:

  • the gastrointestinal organs
  • the movement of material through the stomach and intestines
  • the digestion and absorption of nutrients
  • the removal of waste from the body
  • the liver

What is a gastroenterologist?

A gastroenterologist is a medical professional who specializes in diseases and conditions that affect the digestive organs and structures.

These parts of the body include the:

To become a gastroenterologist, a doctor must complete a 3 year internal medicine residency after medical school. Following this residency, they will undertake 2–3 years of intense, specialized training called a fellowship.

Once they become qualified, gastroenterologists often work closely with other healthcare professionals to provide care to a wide range of people.

A gastroenterologist may work with:

  • hepatologists, who specialize in the liver
  • radiologists, who specialize in imaging
  • oncologists, who specialize in cancer

Why would a person get a referral to a gastroenterologist?

In some cases, doctors need to refer people to medical professionals with specialist knowledge.

A doctor may refer an individual to a gastroenterologist if they suspect that a problem with the digestive system is causing the person's symptoms.

The symptoms of such issues can vary, but they may include:

The gastroenterologist will use their specialist knowledge to assess the person and recommend treatment and management if necessary.

What conditions do gastroenterologists treat?

Gastroenterologists play a role in the diagnosis, treatment, and management of people with conditions such as:

What procedures do they perform?

Gastroenterologists carry out several procedures to diagnose, treat, and manage conditions.

These procedures include:

Endoscopy

During an endoscopy, a gastroenterologist uses a camera that attaches to a long, thin tube called an endoscope to look inside the body.

They insert the endoscope through the mouth, down the throat, and into the esophagus. It sends images back to a screen for monitoring.

A gastroenterologist might perform an endoscopy to investigate symptoms such as:

  • persistent heartburn
  • nausea and vomiting
  • bleeding
  • problems with swallowing
  • stomach pain
  • unexplained weight loss

Colonoscopy and sigmoidoscopy

These procedures are similar to an endoscopy, but they require the gastroenterologist to insert the tube into the rectum, rather than the mouth.

A gastroenterologist can see the entire colon and rectum during a colonoscopy. A sigmoidoscopy only allows them to examine the rectum and lower colon.

During these procedures, gastroenterologists might be looking for:

  • early signs of colon or rectum cancer
  • causes of bowel habit changes
  • causes of specific symptoms, such as abdominal pain, rectal bleeding, or unexplained weight loss

Polypectomy

During a polypectomy, a gastroenterologist will remove one or more polyps from the lining of the bowel.

Polyps are noncancerous growths that can develop on the colon. They are very common, affecting 30% of those over the age of 50 years in the United States.

The gastroenterologist will either remove the polyps with wire loop forceps or use an electric current to burn them off during a colonoscopy.

Esophageal dilation

During esophageal dilation, a gastroenterologist will stretch out a narrowed area of the esophagus.

Acid reflux can scar this muscular tube, narrowing it and making it hard for a person to swallow food.

Layers of excess tissue, cancer of the esophagus, and scarring from radiation treatment can all lead to the same problem.

The gastroenterologist stretches the tube by using a plastic dilator or inflating a balloon. They will usually carry this out during an endoscopy.

The gastroenterologist may sedate the person for the procedure. Alternatively, they may apply a local anesthetic spray to the back of the person's throat.

Summary

A gastroenterologist is a medical professional who specializes in diseases of the digestive system and digestive tract.

A doctor might refer someone to a gastroenterologist if they have symptoms that suggest a problem with the digestive system.

Gastroenterologists can diagnose, treat, and manage a wide range of gut-related conditions.

They also carry out certain medical procedures, such as endoscopies and colonoscopies.

Original Article